Uncoated Aspirin May Be Best for Heart Protection

May 6, 2004 — In case your specialist has you on ibuprofen treatment to avoid heart issues, read this: For heart assurance, plain aspirin may work superior than enteric-coated aspirin. Coated aspirin may be less powerful than plain headache medicine, a modern ponder appears.

Specialists have long advised heart patients almost headache medicine treatment – telling them to require a daily child ibuprofen to cut heart assault or stroke hazard. A small dosage of day by day aspirin can diminish the blood’s ability to clot and cause these events. But considers have moreover shown that up to 30% of people don’t get that advantage.

This study may offer assistance clarify why, says analyst Dermot Cox, BSc, PhD, a pharmacology professor at the Royal College of Surgeons in Dublin, Ireland, in a news discharge.

Cox presented his findings at the American Heart Association’s 5th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Science being held in San Francisco this week.

Enteric-coated ibuprofen is getting to be simpler to discover than standard headache medicine on store shelves notes Cox. The enteric coating is an acid-resistant coating that doesn’t disturb stomach ulcers. With the coating, the aspirin is absorbed within the colon rather than within the stomach, he clarifies.

In any case, while the protective coating makes a difference ulcer sufferers, it dilutes the aspirin’s effects for everyone else, his ponder shows. For most individuals, it’s not a good choice for aspirin treatment.

Plain Ibuprofen vs. Other Aspirin Formulations

In his consider, 75 solid volunteers were haphazardly relegated to take five distinctive headache medicine arrangements: a 75-milligram uncoated aspirin, a 75-milligram measurements of three distinctive enteric-coated aspirins, and Asasantin (a clot-busting drug that contains 25 milligrams of aspirin) twice a day. Baby aspirin the U.S. comes in 81-milligram pills.

It was a arrangement of mini-studies: All volunteers took one type of aspirin for 14 days. At that point they had 14 days without ibuprofen, to clear the aspirin from their frameworks. At that point they took a different aspirin preparation for 14 days.

Blood tests were taken at the begin and end of each aspirin mini-study to measure levels of blood clotting variables. The researchers found that plain aspirin had the leading clot-preventing effect, clarifies Cox. The enteric-coated brands had the most noticeably awful.

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